CAS: 129453-61-8 Manufacturer of Fulve-Strant for Breast Cancer

• Customization: Available
• CAS No.: 129453-61-8
• Formula: C32h47f5o3s
• Model NO.: 99%
• EINECS: 642-998-6
• Type: Pharmaceutical Intermediates
• Appearance: Powder
• Quality: Refined
• Colour: White
• Molecular Weight: 606.77
• Fusing Point: 104-106°c
• Boiling Point: 674.8±55.0 °c(Predicted)
• Storage Condition: Normal Temperature
• Acidity Coefficient (Pka): 10.27±0.70(Predicted)
• Transport Package: Cardboard Bucket
• Specification: 1kg
• Trademark: Hong Kongda
• Origin: Shangdong Province
• HS Code: 2937230000
• Production Capacity: 500kg Per Year

Product Description

Product Description

Breast cancer drug
Fluvestrant is an intramural drug developed by Astrazeneca and approved by the U.S. Food and Drug Administration in April 2002 for the treatment of estrogen receptor-positive metastatic breast cancer in postmenopausal women whose disease has worsened after anti-estrogen therapy. Many breast cancer cells have the estrogen receptor (ER), which stimulates the growth of such tumors. Fluvestrant is a "pure" estrogen receptor antagonist without partial estrogen-like stimulatory effect. It inhibits estrogen signaling pathway by binding, blocking and down-regulating ER. It can competitively bind with ER, and its affinity with ER is close to estrogen. Because it is an endocrine therapy, it will not cause the common adverse reactions of chemotherapy, so it has a good patient compliance. A number of clinical studies have found that 250mg dose of fluvestrine has good therapeutic effect and stable safety in second-line treatment of advanced breast cancer.

 

Action mechanism
Fluvestrant is a steroid anti-estrogen drug, its chemical structure is similar to estradiol, the difference is that it has a linking group at the 7α position; It is an alkylamine analogue of 17β-estradiol, which can antagonize the effect of estrogen by occupying ER and inhibit the activation of genes stimulated by this estrogen, thus affecting estrogen-related processes necessary for cell circulation; Its affinity with ER is close to estrogen. Apoptosis is essential for homeostasis and may be another major mechanism of the therapeutic effects of fluvestrant.

 

Pharmacological action
Fluvestrant has relatively poor oral bioavailability, so it is usually injected intramuscular with lipids as excipients. An open, randomized, multicenter study in postmenopausal women with advanced breast cancer showed no significant difference in pharmacokinetics and side effects of one 5ml or two 2.5ml injections of 250mg, with dose-dependent and individual differences in blood concentrations. There was no significant change in serum LH, FSH or SBHG levels during 7 days of treatment. The drug does not cross the blood-brain barrier and does not cause side effects such as vasomotor. In theory, estrogen inactivation can lead to increased bone turnover and promote osteoporosis, however, no such effect was found in animal models, nor did fluvestrant cause an increase in the replacement marker of bone turnover.

Product Name	Fulve-strant
CAS No.	129453-61-8

 

Company Profile

Jinan Hong Kongda Chemical Co., Ltd. is a high-tech enterprise specializing in the production of chemical raw materials and advanced pharmaceutical intermediates integrating scientific research, production and sales. The headquarter is located in Jinan, the capital of Shandong Province with major pharmaceutical province in China which has strong resource advantages.

The company has a complete production system with more than 150 sets of reaction equipment, covering production facilities for various special reactions such as high temperature, ultra-low temperature and hydrogenation. In order to continuously innovate and optimize the process, the company is equipped with an experienced R&D team, and established long-term and stable cooperative relations with many colleges and research institutes.

"Stable quality, price advantage" is our consistent service tenet, and has won a good reputation in the industry's customer cooperation and service. We hope and look forward to cooperating with you in the future!

Our products:
 

 

Packaging & Shipping

Product packaging
If the weight is less than 25kg, we will pack it in cartons or cardboard drums.
If the weight is greater than or equal to 25kg, we will use cardboard drums or pack according to your requirements.

 

Our Advantages

We could give you: 
1.Best quality in your requirement 
2.Competitive price in China market 
3.mature Technical support 
4.Professional logistic support 
All we want is win-win business. Send yr. inquiries, you will get it!

 

FAQ

1:Can I get some samples before bulk order?
Most of the products need to pay the sample fee, and the freight is borne by us.

2: What's your MOQ?
For the high value product, our MOQ starts from 10g,100g and 1kg.

3: Which kind of payment terms do you accept?
PI will be sent first after confirmation of order,enclosed our bank information.Payment by T/T, Western Union, L/C.

4.How to place an order?
You can contact me through Trademanager, WhatsApp, Skype Online and other contact methods, tell me the product and quantity you need, and then we will give you a quote. If you choose one of the above payment methods, we will arrange the delivery for you.

5:How about your delivery time?
A: Generally, it will take 5 to 7 days after receiving your advance payment.

6:How do you treat quality complaint?
A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.