| CAS No.: | 103980-44-5 |
|---|---|
| Formula: | C19h18cln5o7s3 |
| EINECS: | 600-507-2 |
| Type: | Pharmaceutical Intermediates |
| Appearance: | Powder |
| Quality: | Refined |
| Samples: |
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| Customization: |
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Audited Supplier Description:
Ceftiofur Hydrochloride is the hydrochloride salt form of ceftiofur, a semisynthetic, beta-lactamase-stable, broad-spectrum, third-generation cephalosporin with antibacterial activity. Ceftiofur binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
Uses:
Ceftiofur hydrochloride (ceftiofur) has been approved for treatment against respiratory diseases in many animals.1,3,8-10 The recommended dosage regimen of ceftiofur for the treatment of swine respiratory disease is 3-5 mg/kg body weight (BW) administered intramuscularly once daily for 3-5 consecutive days.
Veterinary Drugs and Treatments:
In swine, ceftiofur HCl injection is labeled for the treatment and control of swine bacterial respiratory disease (swine bacterial pneumonia) associated with Actinobacillus (Haemophilus) pleuropneumoniae, Pasteurella multocida, Salmonella choleraesuis and Streptococcus suis.
In cattle, ceftiofur HCl is labeled for the treatment of the following bacterial diseases: Bovine respiratory disease (BRD, shipping fever, pneumonia) associated with Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni; Acute bovine interdigital necrobacillosis (foot rot, pododermatitis) associated with Fusobacterium necrophorum and Bacteroides melaninogenicus; and acute metritis (0 - 14 days post-partum) associated with bacterial organisms susceptible to ceftiofur.
The intramammary syringe for dry dairy cattle (Spectramast DC?) is labeled for the treatment of subclinical mastitis in dairy cattle at the time of dry off associated with Staphylococcus aureus, Streptococcus dysgalactiae, and Streptococcus uberis. The intramammary syringe for lactating dairy cattle (Spectramast LC?) is labeled for the treatment of clinical mastitis in lactating dairy cattle associated with coagulase-negative staphylococci, Streptococcus dysgalactiae, and Escherichia coli.
Test items |
Enterprise specification | Test results | ||
| Character | White to of-white powder Soluble in N,N-Dimethylacetamide and5% of sodium bicarbonate, slightly solublein methanol |
Of-white powder Soluble in N,N-Dimethylacetamide and 5% of sodium bicarbonate, slightly soluble inmethanol |
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Specific rotation |
-65°~-73° | -66° | ||
| ldentifcation | 1.In the chromatogram of the assay, the retention time of the principal peak in the chromatogram obtained with thetestsolution corresponds to that of the principal peak in the chromatogram obtained with reference solution. 2. lt gives reaction of chloride. |
1.In the chromatogram of the assay,the retention time of the principal peak in the chromatogram obtained withthe testsolution corresponds to that of the principal peak in the chromatogram obtained with reference solution. 2.lt gives reaction of chloride. |
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Color of solution |
No more intensely colored than thereference solution Yellow No.9 or Orange-Yellow No.9 | Be equivalent to reference solution Yellow 9 | ||
Clarity |
No more pronounced than that of reference suspension 1 | Less pronounced than that of reference suspension 1 | ||
Acidity (pH) |
2.0~3.0 | 2.2 | ||
Water |
1.5~4.0% | 3.0% | ||
| Related substances |
Biggest individual impurity |
No more than 0.20% | 0.09% | |
| Total impurities | No more than 1.50% | 0.40% | ||
Heavy metal |
No more than 0.0020% | Less than 0.0020% | ||
Residue on ignition |
No more than 0.20% | 0.04% | ||
Bacterial endotoxin |
No more than 0.2EU/mg | Less than 0.2EU/mg | ||
Sterility |
No growth ofmicro-organisms should occur after 14 days ofincubation | No growth ofmicro-organisms occurs after 14 days of incubation | ||
Purity |
No less than 98.5% | 99.6% | ||
| Assay | Anhydrous and acetone-free | Containing cefiofur hydrochloride no less than 98.0% |
Containing ceftiofur hydrochloride: 99.3% | |
Jinan Hong Kongda Chemical Co., Ltd. is a high-tech enterprise specializing in the production of chemical raw materials and advanced pharmaceutical intermediates integrating scientific research, production and sales. The headquarter is located in Jinan, the capital of Shandong Province with major pharmaceutical province in China which has strong resource advantages.
The company has a complete production system with more than 150 sets of reaction equipment, covering production facilities for various special reactions such as high temperature, ultra-low temperature and hydrogenation. In order to continuously innovate and optimize the process, the company is equipped with an experienced R&D team, and established long-term and stable cooperative relations with many colleges and research institutes.
In order to optimize global resources, protect the environment, and make up for the shortage of some domestic chemical intermediates, the company has established a cooperation center in India to solve domestic shortages.
"Stable quality, price advantage" is our consistent service tenet, and has won a good reputation in the industry′s customer cooperation and service. We hope and look forward to cooperating with you in the future!
Q1 Can i get some samples
A1 Yes, we can supply the free sample, but the shipping cost be paid by our customers.
Q2 How to start orders or make payments
A2 Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T
Q3 How to confirm the Product Quality before placing orders
A3 You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests, we will manufacture the products according to your requests.
Q4 What's your MOQ
A4 Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.
Q5 How about delivery leadtime
A5 Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included)
Q6 Is there a discount
A6 Different quantity has different discount.
Q7 How do you treat quality complaint
A7 First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
Q8 How to contact us
A9 You can chat with us by Trademanager,Skype, Wechat, Whatsapp Online.
You can choose your interested products and send inquiry to us.
You can dial our telephone directly or send Email to us., you will get our reply.
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