Medetomidine is a highly selective α2 adrenergic receptor agonist, which has sedative, hypnotic, analgesic and anti-sympathetic effects, and is widely used in clinical anesthesia and ICU sedation. Because dexmedetomidine has the characteristics of inducing to induce physiological sleep, little respiratory depression, strong neuroprotective effect, and the development of anesthesia therapy and sleep medicine in recent years, dexmedetomidine has been increasingly used in the diagnosis and treatment of sleep disorders.
Medetomidine hydrochloride is an agonist of RECEPTORS, It is the racemate of DEXMEDETOMIDINE. Medetomidine is used as both a surgical anesthetic and analgesic. It is often used as the hydrochloride salt, medetomidine hydrochloride, a crystalline white solid. It is an α2 adrenergic agonist that can be administered as an intravenous drug solution with sterile water.
Function:
1. In Veterinary medicine
Medetomidine hydrochloride is often used in combinations as premedication (before a general anaesthetic) in healthy cats and dogs.
2. In Marine paint
Medetomidine hydrochloride can be used as an antifouling substance in marine paint.
Application:
1. Medetomidine hydrochloride is a selective α2-adrenoceptor agonist, with Ki of 1.08 nM.
2. Medetomidine hydrochloride exhibts 1620-fold selectivity over α1-adrenoceptor.
3. Medetomidine hydrochloride is α2-Adrenergic agonist, Sedative, analgesic.
Loss on drying
|
0.13%
|
Residue on ignition
|
0.04%
|
Heavy metal
|
≤10ppm
|
Assay
|
99.56%
|