| Molecular Weight: | 495.73 |
|---|---|
| Melting Point: | <50 °c |
| Boiling Point: | 615.9±30.0 °c(Predicted) |
| Density: | 0.976±0.06 g/cm3(Predicted) |
| Storage Conditions: | 2-8°c |
| Transport Package: | Cartons |
| Samples: |
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| Customization: |
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Audited Supplier Olistat is currently internationally recognized as a new type of weight loss and lipid-lowering drug, marketed under the name Senico. It was first launched in New Zealand in 1998, with sales of $146 million that year and $538 million in 2007. Currently, Olistat holds 80% of the global weight loss market share, with sales in Hong Kong, China alone reaching $80 million in one year. Olistat is a long-acting and potent specific gastrointestinal lipase inhibitor. It is a white or almost white powder at room temperature, insoluble in water, soluble in chloroform, and easily soluble in ethanol. It inactivates the enzyme by forming covalent bonds with the active serine sites of gastric lipase and pancreatic lipase in the stomach and small intestine. The fat in food cannot be broken down into free fatty acids and monoacylglycerol oil, so fat cannot be absorbed and utilized, thereby reducing the body's calorie intake and controlling weight. This medicine does not require systemic absorption to exert its efficacy. At commonly used doses, fat absorption can be inhibited by 30%. After oral administration, it is rarely absorbed and can be metabolized and inactivated in the intestine. The metabolic site is in the gastrointestinal wall, and the elimination half-life is about 14-19 hours. About 97% of this product is excreted with feces, of which 83% is excreted in its original form. In clinical practice, orlistat can be applied to obesity and hyperlipidemia. In general, 120mg can be taken orally three times a day during meals or one hour after meals. After 2 weeks of medication, weight may begin to decrease. It can be taken continuously for 6-12 months. If the dosage increases to over 400mg per day, its effect will no longer be enhanced.
| Tests | Specifications | Results |
| Description | Appearance: white or almost white crystalline powder | White crystalline powder |
| Melting point | 42 -46°C | 44 -45°C |
| Identification | HPLC: the retention time of principal peak should comply with its RS. | Conforms |
| IR spectrum should, comply with that of its RS. | Conforms | |
| Specific rotation | -48° ~-51°. | -50° |
| Related substance | Any other Single impurity NMT 1.0% | 0.18% |
| Total impurities NMT 2.0% | 0.95% | |
| Residual solvents | Ml NMT 3000ppm | Undetectable |
| NMT 5000ppm | 2000ppm | |
| Water | NMT 0.5% | 0.01% |
| Residue on ignition | NMT 0.1% | 0.02% |
| Heavy metals | NMT 20ppm | Conforms |
| Assay | NLT 98.0% (on the anhydrous basis) | 98.9% |
| Conclusion: Conforms to the requirements of in house standard. | ||
Jinan Hongkongda Chemical Co., Ltd. is a technology driven enterprise focused on chemical raw materials and advanced pharmaceutical intermediates. The company is headquartered in Jinan, as the capital of Shandong Province, a major pharmaceutical province in China, with strong resource advantages. The company has a complete production management system, and the corresponding production base has more than 150 sets of reaction equipment, covering various special reaction production facilities such as high temperature, ultra-low temperature, and hydrogenation. Equipped with an experienced R&D team and established long-term stable cooperative relationships with numerous institutions, in order to continuously innovate and optimize processes. In order to optimize global resources, protect the environment, and make up for the shortage of some chemical intermediates in China, the company has established a cooperation center in India to develop domestically scarce varieties. Over the years, it has established stable cooperative relationships with multiple Indian enterprises and solved the problem of some product supply shortages.
1. The product quality can be guaranteed, and the quality is guaranteed
2. There is a one-on-one sales manager service that can provide technical support
3. Provide quality inspection documents, physical images, liquid chromatography, testing methods, and competitive prices
4. The company has an advantage in inventory and spot goods, and can provide bulk goods at kilogram prices and tonnage
5. Contract making - Contract signing by both parties - Corporate payment - Issuance of 13% value-added tax invoice - Express package shipping - Timely delivery - Real time follow-up of goods - After sales consultation
6. Protecting the legitimate rights and interests of customers is our mission, and quality and service are our unchanging pursuits
7. Long term cooperation with scientific research units in universities such as Beijing, Shanghai, Shenzhen, Xiamen, Guangzhou, Tianjin, Anhui, Chongqing, Changsha, Shenyang, etc
8. Exporting to North America, Central/South America, Western Europe, Eastern Europe, Oceania, Africa and other regions
Q1:Are you trading company or manufacturer?
A1:We are chemical factory in China. So we can provide wholesale price.
Q2:How can I get the samples?
A2:We can provide you sample for our existing products, the lead time is about 1-5 days.You just need to pay the sample fee.
Q3:Is there a discount?
A3:Different quantity has different discount.
Q4:Can you provide relevant documents?
A4:Of course. We can provide Commercial Invoice, Packing List, Bill of loading, COA and Origin certificate.
Q5:Do you accept third party inspection?
A5:Yes.we do.
Q6:How long is your delivery time?
A6:Generally it is with 7 days if the goods are in stock. According to quantity your required,the delivery time may slightly change.
Q7:What's your terms of payment?
A7:We can accept various payment methods, L/C, T/T, Paypal, Western Union etc.
Q8:How do you treat quality complaint ?
A8:First of all, our quality control will reduce the quality problem to near zero. If there is a quality problem caused by us, we will send you free goods for replacement or refund your loss.
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