Security Clearance Medetomidine Hydrochloride 99 Purity CAS: 86347-15-1

• CAS No.: 86347-15-1
• Formula: C13h17cln2
• EINECS: 645-306-0
• Type: Pharmaceutical Intermediates
• Appearance: Powder
• Quality: Refined
• Model NO.: 99%
• Colour: White
• Product Packaging: Foil Pouches
• Melting Point: 164-166°c
• Storage Conditions: Inert Atmosphere,Store in Freezer, Under -20°c
• Molecular Weight: 236.74
• Transport Package: Cartons
• Specification: 1kg
• Trademark: Hong Kongda
• Origin: Jinan
• Production Capacity: 500kg Per Year

Product Description

Appearance	White powder
pH	4.27
Related substances	0.029%
Loss on drying	0.08%
Residue on ignition	0.05%
Clarity and color of solution	Less than turbidity-1;colorless
Assay (on dried basis)	99.49%

Medetomidine HCl is a selective α2-adrenoceptor (α2-adrenoceptor) agonist with a Ki of 1.08 nM, which is 1620-fold more selective than acting on α1-adrenoceptor.

Medetomidine is a selective α2-adrenal receptor agonist with a Ki of 1.08 nM, 1620-fold selectivity over α1-adrenal receptors, and has little or no binding to other neurotransmitter receptors.

In anesthetized rats, medetomidine (1-100 μg/kg, intravenously) causes a dose-dependent transient decrease in blood pressure and heart rate. In brain-destroying spinal cord rats, medetomidine showed potent vasopressor (PD501.7 μg/kg) and sympathetic inhibition (ID501.6 μg/kg) without affecting the basal heart rate. Medetomidine causes a dose-dependent sedative effect, at high doses (>100 mcg / kg), causes a loss of positive reflexes, and lowers body temperature. Medetomidine causes a decrease in biogenic amine turnover in the brain, dose-dependent inhibition of norepinephrine (NE) inversion, inhibition of cerebral dopamine turnover at high doses, and decrease of serotonin reversal.

Medetomidine HCl is a selective α2-adrenoceptor (α2-adrenoceptor) agonist with a Ki of 1.08 nM, which is 1620-fold more selective than acting on α1-adrenoceptor.

Product Description