use
Palonosetron hydrochloride is a serotonin 5-HT3 receptor antagonist used for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Palonosetron hydrochloride is an antiemetic.
Nausea and vomiting drug
Palonosetron hydrochloride is a novel, highly selective, high-affinity 5-HT3 receptor antagonist, which can block the presynaptic 5-HT of peripheral neurons of vomiting reflex. The receptor excites and directly affects 5-HT within the central nervous system. The impulse generated by the receptor excitation is transmitted to the posterior area through the vagus nerve, blocking the vagus nerve endings in the gut and preventing the transmission of the signal to 5-HT. The receptor triggers the region, reducing the incidence of nausea and vomiting. It is clinically used to treat acute, delayed nausea and vomiting caused by moderate and severe emetic chemotherapy drugs. Because of its high curative effect, little side effect, long half-life (about 40h), small dosage and so on, it has attracted much attention.
Palonosetron hydrochloride is a commonly used antiemetic drug in clinical practice. Palonosetron hydrochloride is mainly used to prevent acute nausea and vomiting caused by moderate to severe emetic chemotherapy. Palonosetron hydrochloride capsules can be used for oral administration, or Palomosetron hydrochloride injection can be used for preventive antiemetic treatment before chemotherapy.
Pharmacological action
Palonosetron is a selective antagonist of 5-HT3 receptor with strong affinity, with no affinity or low affinity to other receptors. The 5-HT3 receptor is located in the central and surrounding vagus nerve endings of the emetic chemotherapeutic receptor in the final region of the medulla oblongata. Chemotherapy agents stimulate the release of 5-HT by small intestinal pheochromotropic cells, which in turn activate the 5-HT3 receptor of the vagafferent nerve, producing the vomiting reflex.
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