Palonosetron HCl CAS: 135729-62-3 Antiemetic

• Customization: Available
• CAS No.: 135729-62-3
• Formula: C19h25cln2o
• Model NO.: 99%
• EINECS: 680-630-6
• Type: Pharmaceutical Intermediates
• Appearance: Powder
• Quality: Refined
• Colour: White
• Product Packaging: Aluminum Foil Bag
• Molecular Weight: 332.87
• Storage Condition: Normal Temperature
• Solubility: Slightly Soluble in Water
• Use: Stop Vomiting
• Transport Package: Cardboard Bucket
• Specification: 1kg
• Trademark: Hong Kongda
• Origin: Shangdong Province
• HS Code: 29339900
• Production Capacity: 500kg Per Year

Product Description

Product Description

use

Palonosetron hydrochloride is a serotonin 5-HT3 receptor antagonist used for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Palonosetron hydrochloride is an antiemetic.

 

Nausea and vomiting drug
Palonosetron hydrochloride is a novel, highly selective, high-affinity 5-HT3 receptor antagonist, which can block the presynaptic 5-HT of peripheral neurons of vomiting reflex. The receptor excites and directly affects 5-HT within the central nervous system. The impulse generated by the receptor excitation is transmitted to the posterior area through the vagus nerve, blocking the vagus nerve endings in the gut and preventing the transmission of the signal to 5-HT. The receptor triggers the region, reducing the incidence of nausea and vomiting. It is clinically used to treat acute, delayed nausea and vomiting caused by moderate and severe emetic chemotherapy drugs. Because of its high curative effect, little side effect, long half-life (about 40h), small dosage and so on, it has attracted much attention.

 

Palonosetron hydrochloride is a commonly used antiemetic drug in clinical practice. Palonosetron hydrochloride is mainly used to prevent acute nausea and vomiting caused by moderate to severe emetic chemotherapy. Palonosetron hydrochloride capsules can be used for oral administration, or Palomosetron hydrochloride injection can be used for preventive antiemetic treatment before chemotherapy.

Pharmacological action
Palonosetron is a selective antagonist of 5-HT3 receptor with strong affinity, with no affinity or low affinity to other receptors. The 5-HT3 receptor is located in the central and surrounding vagus nerve endings of the emetic chemotherapeutic receptor in the final region of the medulla oblongata. Chemotherapy agents stimulate the release of 5-HT by small intestinal pheochromotropic cells, which in turn activate the 5-HT3 receptor of the vagafferent nerve, producing the vomiting reflex.

Company Profile

Jinan Hong Kongda Chemical Co., Ltd. is a high-tech enterprise specializing in the production of chemical raw materials and advanced pharmaceutical intermediates integrating scientific research, production and sales. The headquarter is located in Jinan, the capital of Shandong Province with major pharmaceutical province in China which has strong resource advantages.

The company has a complete production system with more than 150 sets of reaction equipment, covering production facilities for various special reactions such as high temperature, ultra-low temperature and hydrogenation. In order to continuously innovate and optimize the process, the company is equipped with an experienced R&D team, and established long-term and stable cooperative relations with many colleges and research institutes.

"Stable quality, price advantage" is our consistent service tenet, and has won a good reputation in the industry's customer cooperation and service. We hope and look forward to cooperating with you in the future!

Our products:

 

Packaging & Shipping

Product packaging
If the weight is less than 25kg, we will pack it in cartons or cardboard drums.
If the weight is greater than or equal to 25kg, we will use cardboard drums or pack according to your requirements.

 

Our Advantages

We could give you: 
1.Best quality in your requirement 
2.Competitive price in China market 
3.mature Technical support 
4.Professional logistic support 
All we want is win-win business. Send yr. inquiries, you will get it!

 

FAQ

1:Can I get some samples before bulk order?
Most of the products need to pay the sample fee, and the freight is borne by us.

2: What's your MOQ?
For the high value product, our MOQ starts from 10g,100g and 1kg.

3: Which kind of payment terms do you accept?
PI will be sent first after confirmation of order,enclosed our bank information.Payment by T/T, Western Union, L/C.

4.How to place an order?
You can contact me through Trademanager, WhatsApp, Skype Online and other contact methods, tell me the product and quantity you need, and then we will give you a quote. If you choose one of the above payment methods, we will arrange the delivery for you.

5:How about your delivery time?
A: Generally, it will take 5 to 7 days after receiving your advance payment.

6:How do you treat quality complaint?
A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.