Raloxifene HCl CAS: 82640-04-8 High Purity 99.0% High Quality and Competitive Price

• CAS No.: 82640-04-8
• Formula: C28h28clno4s
• EINECS: 639-789-7
• Type: Pharmaceutical Intermediates
• Appearance: Powder
• Quality: Refined
• Model NO.: 99% purity
• Colour: Light Yellow
• Purity: 99.0%
• Single Impurity: 0.1%
• Package: 1 Kg Per Bag
• Assay: 99.0%
• Transport Package: 1kg
• Specification: 1kg
• Trademark: Hong Kongda
• Origin: Jinan
• HS Code: 2934999099
• Production Capacity: 5000kg Per Year

Product Description

Product Standard:

Purity	99.0%
Single Impurity	0.1%
Assay	99.0%

This product was launched as Evista in the US for the prevention of postmenopausal osteoporosis. It is noteworthy that this molecule was formerly under development as keoxifene for breast cancer and prostatic hypertrophy. Raloxifene can be prepared by acylation of 6-methoxy-2-(4-methoxyphenyl) benzothiophene followed by simultaneous demethylation of both methoxy groups. Raloxifen is a selective estrogen receptor modulator, exerting antiestrogenic action on certain tissues (breast) and also estrogenic action on bone metabolism or serum lipids. In normal early postmenopausal women, 200 mg daily produced a trend towards suppression of estrogen effects. Raloxifen impeded bone loss in osteoporosis. A two-year study in postmenopausal women with an increased risk for osteoporosis showed that Raloxifen markedly prevented non-traumatic vertebral fractures. Results of several clinical studies demonstrated that Raloxifen appreciably reduced the risk of developing breast cancer. Moreover, it had favourable effect on lipid profiles without having the potential side-effects of estrogen-based therapies. Several extensions for different uses of this molecule are planned, for example growth disorder, obesity, colon tumor and skin atrophy. No serious drug-related events have been reported in the limited number of clinical trials.