| Customization: | Available |
|---|---|
| CAS No.: | 104010-37-9 |
| Formula: | C19h18n5nao7s3 |
|
Still deciding? Get samples of US$ 100/Bag
Request Sample
|
Suppliers with verified business licenses
Audited Supplier Audited by an independent third-party inspection agency
Instruction: Third-generation cephalosporins, Ceftiofur sodium is the sodium salt of ceftiofur, which belongs to the third generation cephalosporin antibiotics, for the first time in 1988 it was listed in the United States. Chemical properties are stabie, appearance is light yellow to white crystalline powder, aqueous solution has a shorter retention time, it should be diluted into a solution before use.
Ceftiofur has a broad antimicrobial spectrum , it has a strong antibacterial activity , it has a strong antibacterial activity against Gram-positive bacteria, Gram-negative bacteria, and some anaerobic bacteria ,its antibacterial activity is similar to or weaker than the first-generation cephalosporins against Gram-positive bacteria , it has a strong antibacterial activity against Gram-negative bacteria such as E. coli, Salmonella, Pasteurella and so on. It is used for a variety of respiratory, urinary tract and other infections caused by sensitive bacteria, especially for the prevention and treatment of early death of chicks caused by E. coli, Salmonella, Pseudomonas aeruginosa, Staphylococcus aureus , E. coli yellow dysentery of 1 piglets and wound infections caused by cutting the umbilical cord, ear numbers, cutting teeth, tails and others,pleuropneumoniae and bovine bronchial pneumonia caused by Haemophilus and Actinobacillus , generally it does not apply to cows and goats mastitis treatment . Some researchers have done ceftiofur sodium inhibition tests for thousands strains of pathogens isolated by veterinary clinically , the results show that the drug is one of the most active anti-bacterial drugs, it has a strong antibacterial activity against Escherichia coli, p.multocida and p.haemolytica ,Bacillus typhosus, Streptococcus ; it also has a good effect on Pseudomonas aeruginosa, Enterobacter, anaerobic bacteria. It is used for the treatment of respiratory disease of sheep,horses, cattle, pigs (pleuropneumonia),and the treatment of pets, day-old broiler infectious diseases. This product has characteristics such as complete intramuscular absorption and long elimination half-life period .
Uses: It belongs to antibiotic medicines for the treatment of swine bacterial respiratory infection
Ceftiofur sodium is resistant to the antibiotic resistance enzyme beta-lactamase, and has activity against Gram-positive and Gram-negative bacteria. E. coli strains resistant to ceftiofur have been reported. The bactericidal activity of ceftiofur results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins. The PBPs are transpeptidases which are vital in peptidoglycan biosynthesis. Therefore, their inhibition prevents this vital cell wall component from being properly synthesized.
Veterinary Drugs and Treatments:
Labeled indications for ceftiofur sodium:
1)In cattle for treatment of bovine respiratory disease (shipping fever, pneumonia) associated with Mannheimia haemolytica, Pasteurella multocida and Histophilus somni. It is also indicated for treatment of acute bovine interdigital necrobacillosis (foot rot, pododermatitis) associated with Fusobacterium necrophorum and Bacteroides melaninogenicus.
2)In swine for treatment/control of swine bacterial respiratory disease (swine bacterial pneumonia) associated with Actinobacillus (Haemophilus) pleuropneumoniae, Pasteurella multocida, Salmonella choleraesuis and Streptococcus suis.
3)In sheep/goats for treatment of sheep/caprine respiratory disease (sheep/goat pneumonia) associated with Mannheimia haemolytica and Pasteurella multocida.
4)In horses for treatment of respiratory infections in horses associated with Streptococcus zooepidemicus. In dogs for the treatment of canine urinary tract infections associated with E. coli and Proteus mirabilis.
5)In day old chicks/poults for the control of early mortality, associated with E. coli organisms susceptible to ceftiofur.
Ceftiofur sodium has also been used in an extra-label manner in a variety of veterinary species (see Doses) to treat infections that likely to be susceptible to a 3rd generation cephalosporin.
Test items |
Enterprise specification | Test results | ||
Character |
White to grayish yellow, odor free and humidifying | Light yellow powder, odor free andhumidifying | ||
| Identification | 1. In the chromatogram of the assay, theretention time of the principal peak in thechromatogram obtained with the testsolution corresponds to that oftheprincipal peak in the chromatogramobtained with reference solution. 2.It gives reaction of chloride. |
1. In the chromatogram of the assay, theretention time of the principal peak in thechromatogram obtained with the testsolution corresponds to that oftheprincipal peak inthechromatogramobtained with reference solution.2.It gives reaction of chloride. | ||
Water |
Not more than 3.0% | 0.79% | ||
Acidity (pH) |
5.5-7.5 | 7.0 | ||
| Color of solution | No more intensely colored than referencesolutionY9 or GY9 | Less intensely coloured than referencesolution Yellow 7 | ||
| Clarity of solution | No more pronounced than that of reference suspension 1 | Less pronounced than that ofreference suspension 0.5 |
||
Assay (Cefiofur) |
No less than 85.0% | 87.7% | ||
| Related substances | Biggest individual impurity | No more than 0.5% | 0.29% | |
| Total impurities | No more than 13.0% | 1.7% | ||
Residual solvents |
Acetone:No more than 2.0% | 1.1% | ||
| Particulate matter | ≥10μ m: no more than 5000 particles/g | 204particles/g | ||
| ≥25 μ m: no more than 500 particles/g | 2particles/g | |||
Bacterial endotoxin |
No more than 0.20EU/mg(Cefiofir) | Less than 0.2EU/mg (Ceftiofur) | ||
| Sterility | No growth ofmicro-organisms shouldoccur afer 14 days of incubation. | No growth of micro-organisms occurs afer 14 days of incubation. | ||
Jinan Hong Kongda Chemical Co., Ltd. is a high-tech enterprise specializing in the production of chemical raw materials and advanced pharmaceutical intermediates integrating scientific research, production and sales. The headquarter is located in Jinan, the capital of Shandong Province with major pharmaceutical province in China which has strong resource advantages.
The company has a complete production system with more than 150 sets of reaction equipment, covering production facilities for various special reactions such as high temperature, ultra-low temperature and hydrogenation. In order to continuously innovate and optimize the process, the company is equipped with an experienced R&D team, and established long-term and stable cooperative relations with many colleges and research institutes.
In order to optimize global resources, protect the environment, and make up for the shortage of some domestic chemical intermediates, the company has established a cooperation center in India to solve domestic shortages.
"Stable quality, price advantage" is our consistent service tenet, and has won a good reputation in the industry′s customer cooperation and service. We hope and look forward to cooperating with you in the future!
Q1 Can i get some samples
A1 Yes, we can supply the free sample, but the shipping cost be paid by our customers.
Q2 How to start orders or make payments
A2 Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T
Q3 How to confirm the Product Quality before placing orders
A3 You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests, we will manufacture the products according to your requests.
Q4 What's your MOQ
A4 Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.
Q5 How about delivery leadtime
A5 Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included)
Q6 Is there a discount
A6 Different quantity has different discount.
Q7 How do you treat quality complaint
A7 First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
Q8 How to contact us
A9 You can chat with us by Trademanager,Skype, Wechat, Whatsapp Online.
You can choose your interested products and send inquiry to us.
You can dial our telephone directly or send Email to us., you will get our reply.
){kind=link}