| CAS No.: | 1094-61-7 |
|---|---|
| Formula: | C11h15n2o8p |
| EINECS: | 214-136-5 |
| Type: | Pharmaceutical Intermediates |
| Appearance: | Crystal |
| Quality: | Refined |
| Samples: |
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| Customization: |
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β- Nicotinamide mononucleotide has a white to slightly yellow appearance and is a crystalline powder with no obvious odor.
Brief Introduction
Nicotinamide mononucleotide, also known as β- Nicotinamide mononucleotide (NMN) is a synthetic substrate for coenzyme I, and NMN is also used in anti-aging research. Research has shown that, β- NMN can also regulate ins ulin secretion and affect mRNA expression levels, β- NMN has broad application prospects in the field of medical treatment. β- Nicotinamide mononucleotide is a product and key NAD+intermediate of the extracellular nicotinamide phosphoribosyltransferase (eNAMPT) reaction. It improves glucose tolerance by restoring NAD+levels in HFD induced T2D mice. It also enhances liver in sulin sensitivity and partially restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm through SIRT1 activation.
Source
Nicotinamide mononucleotide, or NMN for short, is an intrinsic substance in the human body and is also rich in some fruits and vegetables, including broccoli, cabbage, etc. Used in mammals, β- Nicotinamide mononucleotides are generated by the catalysis of nicotinamide (Nam) in Nampt (a protease in vivo), followed by the generation of NAD+by the catalysis of nicotinamide mononucleotide adenosine transferase. Nicotinamide mononucleotide is a direct way to supplement NAD+. Nicotinamide mononucleotides significantly enhance the repair ability of intracellular DChemobookNA damage, ultimately achieving the effect of reversing aging. Nicotinamide mononucleotides are converted into essential nicotinamide adenine dinucleotides (NAD) for energy metabolism in the body. In mouse experiments, it was confirmed that nicotinamide mononucleotide can activate a gene called acetylase in the body, so as to play a role in prolonging life and treating diabetes. NAD is a substance that the human body could originally generate, and research has shown that the content of NAD in the body decreases with age.
Application
β- Nicotinamide mononucleotide is a precursor to the cofactor NAD+of long-lived proteins in the human body. NAD+is an important coenzyme in the tricarboxylic acid cycle, promoting the metabolism of sugars, fats, and amino acids, and participating in energy synthesis; NAD+is the only substrate for coenzyme I consuming enzymes (the only substrate for DNA repair enzyme PARP, the only substrate for long-lived protein Sirtuins, and the only substrate for cyclic ADP ribose synthase CD38/157). NAD+participates in all aspects of human metabolism and is a crucial coenzyme. Without NAD+, metabolism cannot function properly. Elderly people lack NAD+, leading to various small and large problems. By supplementing with NAD+, they can comprehensively combat aging.
Test ltems |
Specification | Result |
Appearance |
White to off-white power | Off-white Powder |
Purity |
≥99.5% | 99.9% |
Sodium Content |
<0.05% | 0.001% |
Water |
<0.5% | 0.43% |
PH |
3.0-4.0 | 3.4 |
Ethanol |
<500ppm | Conform |
Pb |
<0.1 ppm | Conform |
Hg |
<0.1 ppm | Conform |
Cd |
<0.2 ppm | Conform |
AS |
<0.1 ppm | Conform |
Total microbial count |
<500CFU/g | <10 |
Coliform |
≤0.92MPN/g | Conform |
Mold and yeast |
<50CFU/g | Conform |
Staphylococcus aureus |
0/25g | Conform |
Salmonella |
0/25g | Conform |
Bulk density |
0.58g/ml | |
Conclusion |
All inspection items are in conformity with the specifications. | |
Jinan Hongkongda Chemical Co., Ltd. is a technology driven enterprise focused on chemical raw materials and advanced pharmaceutical intermediates. The company is headquartered in Jinan, as the capital of Shandong Province, a major pharmaceutical province in China, with strong resource advantages. The company has a complete production management system, and the corresponding production base has more than 150 sets of reaction equipment, covering various special reaction production facilities such as high temperature, ultra-low temperature, and hydrogenation. Equipped with an experienced R&D team and established long-term stable cooperative relationships with numerous institutions, in order to continuously innovate and optimize processes. In order to optimize global resources, protect the environment, and make up for the shortage of some chemical intermediates in China, the company has established a cooperation center in India to develop domestically scarce varieties. Over the years, it has established stable cooperative relationships with multiple Indian enterprises and solved the problem of some product supply shortages.
1. The product quality can be guaranteed, and the quality is guaranteed
2. There is a one-on-one sales manager service that can provide technical support
3. Provide quality inspection documents, physical images, liquid chromatography, testing methods, and competitive prices
4. The company has an advantage in inventory and spot goods, and can provide bulk goods at kilogram prices and tonnage
5. Contract making - Contract signing by both parties - Corporate payment - Issuance of 13% value-added tax invoice - Express package shipping - Timely delivery - Real time follow-up of goods - After sales consultation
6. Protecting the legitimate rights and interests of customers is our mission, and quality and service are our unchanging pursuits
7. Long term cooperation with scientific research units in universities such as Beijing, Shanghai, Shenzhen, Xiamen, Guangzhou, Tianjin, Anhui, Chongqing, Changsha, Shenyang, etc
8. Exporting to North America, Central/South America, Western Europe, Eastern Europe, Oceania, Africa and other regions
Q1:Are you trading company or manufacturer?
A1:We are chemical factory in China. So we can provide wholesale price.
Q2:How can I get the samples?
A2:We can provide you sample for our existing products, the lead time is about 1-5 days.You just need to pay the sample fee.
Q3:Is there a discount?
A3:Different quantity has different discount.
Q4:Can you provide relevant documents?
A4:Of course. We can provide Commercial Invoice, Packing List, Bill of loading, COA and Origin certificate.
Q5:Do you accept third party inspection?
A5:Yes.we do.
Q6:How long is your delivery time?
A6:Generally it is with 7 days if the goods are in stock. According to quantity your required,the delivery time may slightly change.
Q7:What's your terms of payment?
A7:We can accept various payment methods, L/C, T/T, Paypal, Western Union etc.
Q8:How do you treat quality complaint ?
A8:First of all, our quality control will reduce the quality problem to near zero. If there is a quality problem caused by us, we will send you free goods for replacement or refund your loss.
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