| CAS No.: | 145435-72-9 |
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| Formula: | C40h76n2o12 |
| EINECS: | 604-472-4 |
| Type: | Pharmaceutical Intermediates |
| Appearance: | Powder |
| Quality: | Refined |
| Samples: |
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| Customization: |
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Audited Supplier Gamithromycin is a new type of semi synthetic macrolide veterinary antibiotic, which is one of the representative drugs of the second-generation macrolide antibiotics developed by the French company Meria. It plays a role in inhibiting bacterial RNA dependent protein synthesis and killing bacteria. Jiamimycin has high antibacterial activity against Streptococcus pneumoniae, Bacillus multocida, and Mycoplasma bovis, which cause bovine respiratory disease (BRD). Its antibacterial spectrum is wide, antibacterial activity is strong, and it has the advantages of fast absorption, wide distribution in vivo, low residual in vivo, and high safety. It is widely used abroad for clinical treatment of bovine respiratory system diseases caused by bacterial pathogens such as hemolytic Pasteurella, hemorrhagic and septic Pasteurella, and histophilic bacteria. Its chemical name is 13- [(2,6-dideoxy-3Chemicalbook C-methyl-3-O-methyl-a-L-pyranoxyl) oxygen] -2-ethyl-3,4,10-trimethoxy-3,5,8,10,14-hexamethyl-7-propyl-11- [3,4,6-trimethoxy-3- (dimethylamino) - b-D-pyranoxyl] oxygen] -, (2R, 3S, 4R, 5S, 8R, 10R, 11R, 12S, 13S, 14R) -1- Oxaza-7-nitrocyclic-15- monocyclic. The appearance is white to beige powder, insoluble in water, hygroscopic, stable under high temperature conditions, insensitive to light, and only has one configuration after recrystallization. Jiamimycin is replaced by a single propyl group at the 7 α position, which is a special structure that facilitates its rapid absorption under physiological pH conditions and can maintain a longer action time in the target tissue lungs.
| Tests ltems | Aceeptance Criteria | Results | ||
| Characters | Appearance | White to almost white crystalline powder | white crystalline powder | |
| Solubility | Very freely soluble in dichloromethane, soluble inethanol, practically insoluble in water | Conforms | ||
| Specifie optical rotation | -40"~-44" | -42.4° | ||
| Identification | IR: Conforms to the speetrum of' gamithromycin | Conforms | ||
| PH | 9.0~11.0 (2mg/m1 methanol-water(2:3)) | 10.1 | ||
| Clarity and color ofethanol solution | Solution is clear or not more opalescent than referencesuspension l; and not more intensely coloured thanreterence solution Yl | Conforms | ||
| Residue on Ignition | ≤0.10% | 0.01% | ||
| Heavy metals | ≤10ppm | <10ppm | ||
| pd | ≤1ppm | 0.04ppm | ||
| Water | <2.0% | 0.49% | ||
| Related substances | IMB-2 | ≤0.50% | 0.04% | |
| IMB | ≤0.50% | Not detected | ||
| JM-1 | ≤0.50% | 0.41% | ||
| JM-3 | ≤0.50% | 0.04% | ||
| JM-4 | ≤0.50% | 0.18% | ||
| JM-5 | ≤0.50% | 0.11% | ||
| JM-6 | ≤0.20% | 0.03% | ||
| JM-7 | ≤0.20% | 0.02% | ||
| Other Individual impurity | ≤0.20% | 0.11% | ||
| Total impurity | ≤0.20% | 0.94% | ||
| Residual solvents | l)Methanol | <3000ppm | 36ppm | |
| 2)Ethanol | <5000ppm | 2183ppm | ||
| 3)Acetone | <5000ppm | 3062ppm | ||
| 4)Dichloromethane | <6000ppm | Not detected | ||
| 5)Propanal | <5000ppm | Not detected | ||
| 6)Diisopropylamine | <5000ppm | Not detected | ||
| 7)Acetic Acid | <5000ppm | 142ppm | ||
| Assay | C40H76N2012 should be98.0%~102.0%(anhydrous substance) | 99.6% | ||
| Microbial enumeration tests | Total Aerobic Microbial Count ≤2000 cfu/g | <1 cfu/g | ||
| Total Yeast and Mold Count ≤200 cfu/g | 1 cfu/g | |||
| Test for specified microorganisms | Absent in 1g: Escherichia coil | Not detected | ||
| Absent in 1g: Staphylococcus aureus subsp.aures | Not detected | |||
| Absent in 1g: Pseudomonas acruginosa | Not detected | |||
| Bacterial endotoxins | <0.25 EU/mg | <0.125EU/mg | ||
Jinan Hong Kongda Chemical Co., Ltd. is a high-tech enterprise specializing in the production of chemical raw materials and advanced pharmaceutical intermediates integrating scientific research, production and sales. The headquarter is located in Jinan, the capital of Shandong Province with major pharmaceutical province in China which has strong resource advantages.
The company has a complete production system with more than 150 sets of reaction equipment, covering production facilities for various special reactions such as high temperature, ultra-low temperature and hydrogenation. In order to continuously innovate and optimize the process, the company is equipped with an experienced R&D team, and established long-term and stable cooperative relations with many colleges and research institutes.
In order to optimize global resources, protect the environment, and make up for the shortage of some domestic chemical intermediates, the company has established a cooperation center in India to solve domestic shortages.
"Stable quality, price advantage" is our consistent service tenet, and has won a good reputation in the industry′s customer cooperation and service. We hope and look forward to cooperating with you in the future!
Q1 Can i get some samples
A1 Yes, we can supply the free sample, but the shipping cost be paid by our customers.
Q2 How to start orders or make payments
A2 Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T
Q3 How to confirm the Product Quality before placing orders
A3 You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests, we will manufacture the products according to your requests.
Q4 What's your MOQ
A4 Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.
Q5 How about delivery leadtime
A5 Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included)
Q6 Is there a discount
A6 Different quantity has different discount.
Q7 How do you treat quality complaint
A7 First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
Q8 How to contact us
A9 You can chat with us by Trademanager,Skype, Wechat, Whatsapp Online.
You can choose your interested products and send inquiry to us.
You can dial our telephone directly or send Email to us., you will get our reply.
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