Broad-spectrum antifungal agents
The product is a synthetic triazole derivative. It is a synthetic broad-spectrum antifungal drug. Its antibacterial spectrum and antibacterial mechanism are similar to clotrimazole, but it has strong antibacterial activity against aspergillus, exerts antibacterial activity by changing the permeability of fungal cell membrane, and has antibacterial activity against pathogens of superficial and deep fungal infections, and its antibacterial spectrum is broader and stronger than ketoconazole. It can inhibit the synthesis of ergosterol in fungal cell membrane and exert antifungal effect. This product is used against dermatophyton (Trichophyton, Microsporon, Epidermophyton floccus), yeast [Cryptococcus neoformans, Saccharorrhoides, Candida (including Candida albicans, Candida glabra and Candida Cruxalis)], Aspergillus, Histoplasmosis, Paracoccidioides brasiliensis, Sporotrichum Schenckii, Pigmentomyces, cladosporium, dermatitis and various others The yeast and fungi have inhibitory effects. But the product could not inhibit the growth of rhizopus and Mucor.
Clinical application and indication
The product is indicated for the treatment of:
1, for systemic fungal infections such as aspergillosis, candidiasis, cryptococcosis (including cryptococcal meningitis), histiocytosis, sporotrichosis, Brazilian paraccidioidosis, blastomycosis and a variety of other rare systemic or tropical fungal diseases. 2, for oral, pharyngeal (foreign data), esophageal (foreign data), vulvovaginal candida infection, as well as fungal conjunctivitis, fungal keratitis.
3, for superficial fungal infections, such as tinea pedis, tinea corporis, tinea corporis, tinea versicolor, etc.
4. For onychomycosis caused by dermatophyton and (or) yeast.
A nitrogen atom in the product can bind to the iron ion on heme in P450 in fungal cells, thus inhibiting the 14α-methylation of lanosterol catalyzed by P450 hydroxylase, blocking the transformation of lanosterol to ergosterol, causing accumulation of lanosterol and other precursors, changes in membrane chemical composition, dysfunction of membrane binding enzyme, and increased permeability. Intracellular fluid spills, thus achieving inhibition and bactericidal effects. The binding of this product to the fungal P450 system is quite strong and the binding to the mammalian P450 system is weak, so that the toxicity of the drug to humans is greatly reduced. Clinical The product is mainly used for systemic infections caused by deep fungi, such as blastomycosis, histoplasmosis, coccidioidomycosis, pigmentomycosis, sporotrichosis, coccidioidomycosis, etc. It can also be used for candidiasis and aspergillosis.
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Product Name
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The product |
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CAS No.
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84625-61 -6
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Audited Supplier 
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