Factory Prices Levodropropizine Powder CAS 99291-25-5

• CAS No.: 99291-25-5
• Formula: C13h20n2o2
• EINECS: 640-087-8
• Type: Pharmaceutical Intermediates
• Appearance: Powder
• Quality: Refined
• Model NO.: 99%
• Colour: White
• Product Packaging: Foil Pouches
• Melting Point: 98-100°c
• Boiling Point: 412.7±34.0 °c(Predicted)
• Density: 1.168±0.06 g/cm3(Predicted)
• Transport Package: Cardboard Box
• Specification: 1kg
• Trademark: Hong Kongda
• Origin: Jinan
• HS Code: 29335953
• Production Capacity: 5000kg Per Year

Product Description

Molecular Weight	236.315
Density	1.168
Refractive Index	1.57
Specification	98%

Levodropropizine is a chiral antitussive drug first launched by Dompe'Farm in Italy, which inhibits the cough reflex by acting on the C-fibers in the respiratory tract, and is clinically used for the treatment of dry cough without phlegm, compared with other existing antitussive drugs, this product is a peripheral antitussive drug, which has almost no effect on the central system, it has good selectivity, strong antitussive effect, and no drowsiness, respiratory depression, Dependence and other side effects, it has fewer side effects as compared to racemates.

In rats, the central sedative effect of levodropropizine is weaker than that of racemic tartrate, and it does not cause physical dependence. Levodropropizine (15 mg/kg, intravenously) simultaneously reduces the duration of asphyxia and the response of C-fibers to phenyl biguanide. LVDP-induced inhibition of C-fiber response to PBG is averaged 50% in pulmonary fibers and 25% in non-pulmonary fibers. Levodropropizine has been shown to have good antitussive activity in anesthetized guinea pigs and rabbits. In guinea pigs and rabbits with mechanically and electrically induced cough, the activity of levodropropizine (intravenously) is 1/10 to 1/20 that of , while similar to hydroxypropiperazine. Levodropropizine (oral chemicalbook) is similar to hydroxyproproziine and  in the treatment of cough caused by irritating aerosols. Levodropropizine (40 mcg/50 μl, i.c.v.) There is no effect on electrically induced cough, whereas  (5 mcg/50 μL, i.c.v.) Significantly prevents coughing in guinea pigs. Levodropropizine has a secondary site of action, which is associated with sensory neuropeptides. In rat trachea, Levodropropizine (10 mg/kg, 50 mg/kg, as well as 200 mg/kg) dose-dependently reduces capsaicin-induced spillage of Evansblue dye. Levodropropizine (200 mg/kg) inhibits extravasation of substance P, but it does not affect platelet-activating factor-induced extravasation.

Product Description