| Customization: | Available |
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| Shape: | Liquid |
| Storage Condition: | Dark at Room Temperature |
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Pharmacological action:Antiparasitic drug.
Pharmacodynamics: Imidacloprid is a new generation of chlorinated nicotine insecticides. It has a high affinity for postsynaptic nicotinic acetylcholine receptors in the central nervous system of insects, and can inhibit the activity of acetylcholine, leading to parasite paralysis and death. It is effective against adult fleas and young fleas at various stages, and also has a killing effect on young fleas in the environment. The mechanism of action of moxidectin is similar to that of abamectin and ivermectin, and it has a good killing effect on internal and external parasites, especially nematodes and arthropods. The release of butyric acid (GABA) increases its binding force to the postsynaptic receptor, and the chloride channel opens. Moxidectin also has selectivity and high affinity for glutamate-mediated chloride ion channels, thereby interfering with neuromuscular signal transmission, relaxing and paralyzing the parasites, leading to the death of the parasites. Inhibitory interneurons and excitatory motor neurons in nematodes are its sites of action, while in arthropods it is the neuromuscular junction. The combination of the two has a synergistic effect.
Pharmacokinetics: After the first administration, imidacloprid was rapidly distributed to the dog's body surface on the same day, and remained on the body surface during the administration interval. 4-9 days after administration, the plasma concentration of moxidectin in dogs reaches the highest level, and it is distributed throughout the body within one month and is slowly metabolized and excreted.
Indications:
For the prevention and treatment of internal and external parasitic infections in dogs.
Prevention and treatment of flea infestations (Ctenocephalic canis), treatment of lice infestations (Catonicus canis), treatment of ear mite infestations (Itchy otica), canine sarcoids (Scabies mites), and demodicosis (Demodex canis) , for the treatment of Angiostrongylus and gastrointestinal nematode infections (adults, immature adults and L4 larvae of Toxocara canis, Ancylostoma canis, and Ancylocephalus larvae; adults of Toxocara lionis and Trichocephala vixensis). And can be used as an adjuvant treatment of allergic dermatitis caused by fleas.
| Dog weight (kg) | Applicable product type | Specification(ml) | Imidacloprid (mg/kg body weight) | Moxidectin (mg/kg body weight) |
| ≤4kg | drops for small dogs | 0.4ml | Not less than 10 | Not less than 2.5 |
| >4-10kg | medium dog drops | 1.0ml | 10-25 | 2.5-6.25 |
| >10-25kg | large dog drops | 2.5ml | 10-25 | 2.5-6.25 |
| >25-40kg | extra large dog drops | 4.0ml | 10-16 | 2.5-4 |
| >40kg | Reasonable combination of products of different specifications | |||
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